Glucose concentrations in the body vary due to different rates of glucose utilization by different body tissues. The varying rates of glucose utilization may be due to varying amounts of muscle and fat tissue in parts of the body, muscular activity, and variations in blood flow. It is not known which of the sites reflects blood glucose values of greatest physiological significance with regard to managing diabetes. When blood glucose is changing rapidly (e.g., within 2-hours of eating, exercising, or bolus insulin administration), only blood samples from fingertip testing should be used.